Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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ube2sUbiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (221 aa)    
Predicted Functional Partners:
anapc11
APC11 anaphase-promoting complex subunit 11 homolog (yeast).
    
 0.998
cdc27
Cell division cycle 27.
   
 0.997
anapc2
Anaphase-promoting complex subunit 2; Belongs to the cullin family.
    
 0.996
cdc20
Cell division cycle 20 homolog.
   
 0.996
fzr1a
Fizzy/cell division cycle 20 related 1 (Drosophila).
   
 0.990
cdc23
CDC23 (Cell division cycle 23, yeast, homolog).
   
 0.990
fzr1b
Fizzy/cell division cycle 20-related 1b.
    
 0.989
anapc10
Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
   
 0.987
anapc5
Anaphase-promoting complex subunit 5.
    
 0.983
anapc13
Anaphase-promoting complex subunit 13.
    
 0.967
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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