Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mfsd2abSodium-dependent lysophosphatidylcholine symporter 1-B; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and [...] (523 aa)    
Predicted Functional Partners:
fam234b
Family with sequence similarity 234 member B.
      
 0.738
pcmt
Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).
      
 0.719
mfsd11
Major facilitator superfamily domain-containing 11.
      
 0.697
pcmtl
Protein-L-isoaspartate O-methyltransferase.
      
 0.682
mfsd13a
Major facilitator superfamily domain-containing 13A.
      
 0.667
abraa
Actin-binding Rho-activating protein a.
      
 0.667
mfsd9
Major facilitator superfamily domain-containing 9.
      
 0.635
mfsd6l
Major facilitator superfamily domain-containing protein 6-like.
      
 0.627
crygm2d10
Crystallin, gamma M2d10; Belongs to the beta/gamma-crystallin family.
      
 0.596
svopl
Putative transporter SVOPL.
      
 0.595
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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