Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
glra1Glycine receptor subunit alphaZ1; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity); Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. (459 aa)    
Predicted Functional Partners:
glrba
Glycine receptor betaZ subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
0.952
gphnb
Gephyrin2 isoform.
    
 
 0.870
gphna
Gephyrin a.
    
 
 0.868
glra2
Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
     
  0.866
glrbb
Glycine receptor beta subunit 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
0.845
glra3
Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
     
  0.830
slc6a5
Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
   
  
 0.726
slc5a6b
Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      
 0.594
slc6a9
Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
      
 0.578
slc32a1
Solute carrier family 32 (GABA vesicular transporter), member 1.
   
  
 0.546
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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