Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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cacna1baVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2312 aa)    
Predicted Functional Partners:
RASGRF1
Si:ch211-234p18.3.
   
 
  0.874
rasgrp3
RAS guanyl-releasing protein 3 (calcium and DAG-regulated).
     
  0.871
rasgrp4
RAS guanyl-releasing protein 4.
     
  0.871
RASGRP2
RAS guanyl releasing protein 2.
     
  0.871
rasgrf2b
Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and rac1 through the exchange of bound GDP for GTP. May function in synaptic plasticity.
   
 
  0.868
CACNA2D1
Si:dkey-266j7.2.
    
 0.827
cacna1aa
Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a.
  
 
0.809
cacna1ab
Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b.
  
  
0.795
cacna1e
Calcium channel, voltage-dependent, R type, alpha 1E subunit a.
  
  
0.789
scn2b
Voltage-gated sodium channel beta 2 subunit splice variant D.
   
 0.787
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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