STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ugcgUDP-glucose ceramide glucosyltransferase. (438 aa)    
Predicted Functional Partners:
sgms2a
Sphingomyelin synthase 2a.
     
 0.974
gba2
Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
     
 0.973
ugt8
UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family.
   
 
 0.969
degs1
Delta(4)-desaturase, sphingolipid 1.
   
 
 0.965
cers3b
Ceramide synthase 3b.
   
 
 0.965
cerk
Ceramide kinase.
    
 0.964
smpd1
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.
     
 0.962
acer1
Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine.
     
 0.958
asah1b
N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family.
     
 0.956
acer2
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
     
 0.956
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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