STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rps6kalRibosomal protein S6 kinase alpha-6; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (740 aa)    
Predicted Functional Partners:
mapk1
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.937
mapk3
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.937
atf4a
Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity).
   
 
 0.906
atf4b
Activating transcription factor 4b.
     
 0.904
pkmyt1
Protein kinase, membrane-associated tyrosine/threonine 1.
     
 
0.900
bub1
BUB1 mitotic checkpoint serine/threonine kinase.
     
  0.900
ppp2r3b
Protein phosphatase 2, regulatory subunit B'', beta.
      
 0.856
sh3bgrl
SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family.
      
 0.807
colgalt2
Novel protein similar to vertebrate glycosyltransferase 25 domain containing 1 (GLT25D1).
      
 0.741
tsc1a
TSC complex subunit 1a.
   
 0.740
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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