STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
six4bSIX homeobox 4b. (615 aa)    
Predicted Functional Partners:
eya1
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.833
znrf2a
Zinc and ring finger 2a.
      
 0.731
scn4aa
Sodium channel protein type 4 subunit alpha A; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.
   
  
 0.697
atp1a2a
Sodium/potassium-transporting ATPase subunit alpha.
   
  
 0.678
arhgef12a
Rho guanine nucleotide exchange factor (GEF) 12a.
      
 0.669
dlx3b
Homeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family.
   
  
 0.661
gdpd4a
Glycerophosphodiester phosphodiesterase domain-containing 4a.
   
  
 0.605
kcnq5a
Potassium voltage-gated channel, KQT-like subfamily, member 5a; Belongs to the potassium channel family.
      
 0.560
eya2
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.556
arhgef7a
Rho guanine nucleotide exchange factor (GEF) 7a.
      
 0.554
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.