STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
htra1aSerine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] (479 aa)    
Predicted Functional Partners:
cfb
Complement factor B; Belongs to the peptidase S1 family.
   
 
 0.681
cfbl
Complement factor b,-like; Belongs to the peptidase S1 family.
    
 
 0.677
sgk2a
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
      
 0.628
tspan13a
Zgc:91858 protein; Belongs to the tetraspanin (TM4SF) family.
   
  
 0.574
arl4d
ADP-ribosylation factor-like 4D.
      
 0.515
ndufab1b
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
  
 
 0.507
gpd1c
Glycerol-3-phosphate dehydrogenase [NAD(+)].
  
  
 0.502
dqx1
DEAQ box RNA-dependent ATPase 1.
   
  
 0.484
pcare1
Uncharacterized protein.
      
 0.482
adcy2b
Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
      
 0.479
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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