| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birc6 | htra1a | ENSDARP00000128806 | ENSDARP00000048135 | Baculoviral IAP repeat-containing 6. | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | 0.541 |
| birc6 | xiap | ENSDARP00000128806 | ENSDARP00000018322 | Baculoviral IAP repeat-containing 6. | X-linked inhibitor of apoptosis. | 0.462 |
| cfb | cfbl | ENSDARP00000072059 | ENSDARP00000091557 | Complement factor B; Belongs to the peptidase S1 family. | Complement factor b,-like; Belongs to the peptidase S1 family. | 0.413 |
| cfb | cfh | ENSDARP00000072059 | ENSDARP00000136634 | Complement factor B; Belongs to the peptidase S1 family. | Complement factor H. | 0.889 |
| cfb | htra1a | ENSDARP00000072059 | ENSDARP00000048135 | Complement factor B; Belongs to the peptidase S1 family. | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | 0.591 |
| cfbl | cfb | ENSDARP00000091557 | ENSDARP00000072059 | Complement factor b,-like; Belongs to the peptidase S1 family. | Complement factor B; Belongs to the peptidase S1 family. | 0.413 |
| cfbl | cfh | ENSDARP00000091557 | ENSDARP00000136634 | Complement factor b,-like; Belongs to the peptidase S1 family. | Complement factor H. | 0.890 |
| cfbl | htra1a | ENSDARP00000091557 | ENSDARP00000048135 | Complement factor b,-like; Belongs to the peptidase S1 family. | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | 0.507 |
| cfh | cfb | ENSDARP00000136634 | ENSDARP00000072059 | Complement factor H. | Complement factor B; Belongs to the peptidase S1 family. | 0.889 |
| cfh | cfbl | ENSDARP00000136634 | ENSDARP00000091557 | Complement factor H. | Complement factor b,-like; Belongs to the peptidase S1 family. | 0.890 |
| cfh | htra1a | ENSDARP00000136634 | ENSDARP00000048135 | Complement factor H. | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | 0.559 |
| htra1a | birc6 | ENSDARP00000048135 | ENSDARP00000128806 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Baculoviral IAP repeat-containing 6. | 0.541 |
| htra1a | cfb | ENSDARP00000048135 | ENSDARP00000072059 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Complement factor B; Belongs to the peptidase S1 family. | 0.591 |
| htra1a | cfbl | ENSDARP00000048135 | ENSDARP00000091557 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Complement factor b,-like; Belongs to the peptidase S1 family. | 0.507 |
| htra1a | cfh | ENSDARP00000048135 | ENSDARP00000136634 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Complement factor H. | 0.559 |
| htra1a | lmod1b | ENSDARP00000048135 | ENSDARP00000104330 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Leiomodin 1b (smooth muscle). | 0.488 |
| htra1a | pink1 | ENSDARP00000048135 | ENSDARP00000014981 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | PTEN-induced kinase 1. | 0.560 |
| htra1a | sgk2a | ENSDARP00000048135 | ENSDARP00000114309 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.516 |
| htra1a | tspan13a | ENSDARP00000048135 | ENSDARP00000090549 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Zgc:91858 protein; Belongs to the tetraspanin (TM4SF) family. | 0.510 |
| htra1a | umodl1 | ENSDARP00000048135 | ENSDARP00000090626 | Serine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] | Uromodulin-like 1. | 0.509 |
