Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dlg4Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity. (707 aa)    
Predicted Functional Partners:
syn1
Synapsin I.
   
  
 0.920
gphnb
Gephyrin2 isoform.
   
  
 0.892
gphna
Gephyrin a.
   
  
 0.891
grin1b
Glutamate receptor, ionotropic, N-methyl D-aspartate 1b.
   
 0.872
nlgn1
Neuroligin 1.
   
 
 0.834
slc17a7a
Solute carrier family 17 member 7a.
      
 0.817
cdk5
Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily.
    
 0.812
bdnf
Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.
   
  
 0.810
grin1a
Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.
   
 0.786
grin2bb
Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b.
   
 0.785
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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