Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
asb4Ankyrin repeat and SOCS box-containing 4. (435 aa)    
Predicted Functional Partners:
hif1an
Hypoxia-inducible factor 1-alpha inhibitor; Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins.
    
 
 0.812
dnajb5
DnaJ heat shock protein family (Hsp40) member B5.
   
   0.798
asb6
Ankyrin repeat and SOCS box-containing 6.
  
   
 0.784
cul5a
Cullin 5a; Belongs to the cullin family.
    
 
 0.739
cul5b
Cullin 5b; Belongs to the cullin family.
    
 
 0.728
lrrc20
Leucine-rich repeat-containing 20.
    
 0.724
wdr6
WD repeat domain 6.
   
 
 0.721
lrrc30a
Leucine-rich repeat-containing 30a.
   
 0.701
lrrc38a
Leucine-rich repeat-containing 38a.
    
 0.695
lrrc14b
Leucine-rich repeat-containing protein 14B; Belongs to the PRAME family. LRRC14 subfamily.
   
  
 0.669
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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