Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
cryba1aCrystallin, beta A1a; Belongs to the beta/gamma-crystallin family. (196 aa)    
Predicted Functional Partners:
cryaa
Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family.
   
 
 0.977
cryaba
Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family.
    
 
 0.961
gja3
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.876
BFSP1
Beaded filament structural protein 1.
   
  
 0.840
bfsp2
Beaded filament structural protein 2, phakinin; Belongs to the intermediate filament family.
   
  
 0.816
crybb2
Crystallin, beta B2; Belongs to the beta/gamma-crystallin family.
   
 
0.765
grifin
Grifin; Binds lactose.
   
  
 0.758
pitx3
Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily.
      
 0.712
chmp4ba
Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
      
 0.688
zbtb47a
Zinc finger and BTB domain-containing 47a.
      
 0.681
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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