Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rassf2aRas association domain family member 2a. (325 aa)    
Predicted Functional Partners:
stk3
Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...]
   
 0.916
carnmt1
Carnosine N-methyltransferase 1.
      
 0.720
RASSF5
Si:dkey-85p17.3.
    
 
0.692
letmd1
LETM1 domain-containing 1.
      
 0.686
eif5b
Eukaryotic translation initiation factor 5B.
    
 
 0.669
lysmd2
LysM and putative peptidoglycan-binding domain-containing protein 2.
   
  
 0.669
smpdl3a
Acid sphingomyelinase-like phosphodiesterase.
      
 0.662
sav1
Salvador family WW domain-containing protein 1.
    
 
 0.631
stk17b
Serine/threonine kinase 17B (Apoptosis-inducing); Belongs to the protein kinase superfamily.
      
 0.595
znf574
Zinc finger protein 574.
      
 0.595
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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