Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ascc2Activating signal cointegrator 1 complex subunit 2. (768 aa)    
Predicted Functional Partners:
ascc3
Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for alkbh3, enabling alkbh3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions.
    
 
 0.999
ascc1
Activating signal cointegrator 1 complex subunit 1.
   
 
 0.998
trip4
Thyroid hormone receptor interactor 4.
   
 
 0.998
alkbh3
AlkB homolog 3, alpha-ketoglutarate-dependent dioxygenase.
    
 
 0.974
rnf113a
Zinc finger protein 183-like 1.
      
 0.885
crnkl1
Crooked neck pre-mRNA-splicing factor 1.
   
  
 0.881
rps3
Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.
    
 
 0.834
rabepk
Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport.
      
 0.813
pelo
Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
   
  
 0.797
kansl2
KAT8 regulatory NSL complex subunit 2.
      
 0.789
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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