STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ipmkbKinase; Belongs to the inositol phosphokinase (IPK) family. (372 aa)    
Predicted Functional Partners:
itpk1a
Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. May also act as an isomerase that interconverts the inositol tetrakisphos [...]
     
 0.977
itpk1b
Inositol-tetrakisphosphate 1-kinase b.
     
 0.968
ippk
Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation. InsP6 also acts as a key regulator of left- right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification.
     
 0.955
itpkca
Kinase; Belongs to the inositol phosphokinase (IPK) family.
   
 
 0.947
minpp1b
Multiple inositol-polyphosphate phosphatase 1b; Belongs to the histidine acid phosphatase family.
    
 0.928
minpp1a
Multiple inositol-polyphosphate phosphatase 1a; Belongs to the histidine acid phosphatase family.
    
 0.928
itpkb
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.921
inpp5jb
Inositol polyphosphate-5-phosphatase Jb.
     
 0.907
inpp5ka
Inositol polyphosphate-5-phosphatase Ka.
     
 0.907
inpp5kb
Inositol polyphosphate-5-phosphatase Kb.
     
 0.907
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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