Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ognbOsteoglycin, paralog b. (245 aa)    
Predicted Functional Partners:
dcn
Decorin; May affect the rate of fibrils formation. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
   
  
 0.643
olfml3b
Olfactomedin-like protein 3A; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity); Belongs to the OLFML3 family.
   
 
 0.590
cnpy3
Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity).
    
   0.585
ptn
Pleiotrophin.
   
  
 0.511
postna
Periostin, osteoblast-specific factor a.
   
  
 0.418
postnb
Periostin, osteoblast-specific factor b.
   
  
 0.418
abhd6b
Abhydrolase domain-containing 6b.
    
 0.415
abhd6a
Abhydrolase domain-containing 6a.
    
 0.415
lum
Lumican.
   
  
 0.412
cenpp
Centromere protein P; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-P/CTF19 family.
      
 0.409
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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