Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
runx2bRUNX family transcription factor 2b. (478 aa)    
Predicted Functional Partners:
sp7
Sp7 transcription factor.
   
 0.959
fosab
V-fos FBJ murine osteosarcoma viral oncogene homolog Ab.
    
 0.842
cbfb
Core-binding factor subunit beta.
    
 
 0.837
sox9a
HMG box transcription factor Sox9a.
   
 
 0.826
col10a1a
Collagen, type X, alpha 1a.
    
 
 0.801
spi1b
SI:bY184L24.2.1 (Transcription factor spi1).
   
  0.761
bglap
Osteocalcin.
    
 
 0.751
bmp2b
Bone morphogenetic protein 2b.
    
 
 0.750
ctsk
Cathepsin K; Belongs to the peptidase C1 family.
   
  
 0.744
mecom
MDS1 and EVI1 complex locus.
    
 0.741
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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