Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pthlhaParathyroid hormone-like hormone a. (198 aa)    
Predicted Functional Partners:
pth1r
Parathyroid hormone receptor PTH1R; Belongs to the G-protein coupled receptor 2 family.
    
 0.996
pth3r
Parathyroid hormone 1 receptor b; Belongs to the G-protein coupled receptor 2 family.
    
 0.992
pth4
Parathyroid hormone 4; Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra, pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development.
     
 0.980
pthlhb
Parathyroid hormone-related peptide 2.
  
  
0.954
pth2ra
Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.887
pth1a
Parathyroid hormone 1a.
      
 0.818
ihhb
Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation.
      
 0.800
pth2
Tuberoinfundibular peptide of 39 residues; Plays a role as a potent and selective agonist of pth2r resulting in adenyl cyclase activation and intracellular calcium level elevation; Belongs to the parathyroid hormone family.
      
 0.791
pth2rb
Si:dkeyp-4h4.1; Belongs to the G-protein coupled receptor 2 family.
    
  0.755
kpnb1
Karyopherin (importin) beta 1.
    
   0.740
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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