STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pthlhaParathyroid hormone-like hormone a. (198 aa)    
Predicted Functional Partners:
pth1r
Parathyroid hormone receptor PTH1R; Belongs to the G-protein coupled receptor 2 family.
    
 0.974
pth2
Tuberoinfundibular peptide of 39 residues; Plays a role as a potent and selective agonist of pth2r resulting in adenyl cyclase activation and intracellular calcium level elevation; Belongs to the parathyroid hormone family.
     
 0.898
pth3r
Parathyroid hormone 1 receptor b; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.895
pth2ra
Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.887
ihhb
Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation.
      
 0.850
pth1a
Parathyroid hormone 1a.
     
 0.850
kpnb1
Karyopherin (importin) beta 1.
    
 
 0.817
pth1b
Parathyroid hormone ligand type-2.
     
 0.789
col10a1a
Collagen, type X, alpha 1a.
      
 0.670
pth4
Parathyroid hormone 4; Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra, pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development.
      
 0.669
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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