| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cdh5 | kdr | ENSDARP00000104309 | ENSDARP00000049203 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.960 |
| cdh5 | nrp1a | ENSDARP00000104309 | ENSDARP00000140900 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | 0.522 |
| cdh5 | vegfaa | ENSDARP00000104309 | ENSDARP00000133415 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. | 0.586 |
| cdh5 | vegfc | ENSDARP00000104309 | ENSDARP00000092263 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.549 |
| kdr | cdh5 | ENSDARP00000049203 | ENSDARP00000104309 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.960 |
| kdr | nrp1a | ENSDARP00000049203 | ENSDARP00000140900 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | 0.997 |
| kdr | nrp1b | ENSDARP00000049203 | ENSDARP00000089037 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Neuropilin 1b. | 0.981 |
| kdr | ptk2ab | ENSDARP00000049203 | ENSDARP00000042715 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.964 |
| kdr | pxna | ENSDARP00000049203 | ENSDARP00000148251 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.956 |
| kdr | pxnb | ENSDARP00000049203 | ENSDARP00000080428 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.956 |
| kdr | vegfaa | ENSDARP00000049203 | ENSDARP00000133415 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. | 0.997 |
| kdr | vegfab | ENSDARP00000049203 | ENSDARP00000120079 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. | 0.975 |
| kdr | vegfc | ENSDARP00000049203 | ENSDARP00000092263 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.999 |
| kdr | vegfd | ENSDARP00000049203 | ENSDARP00000121602 | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.995 |
| nrp1a | cdh5 | ENSDARP00000140900 | ENSDARP00000104309 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.522 |
| nrp1a | kdr | ENSDARP00000140900 | ENSDARP00000049203 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.997 |
| nrp1a | ptk2ab | ENSDARP00000140900 | ENSDARP00000042715 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.432 |
| nrp1a | vegfaa | ENSDARP00000140900 | ENSDARP00000133415 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. | 0.936 |
| nrp1a | vegfab | ENSDARP00000140900 | ENSDARP00000120079 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. | 0.484 |
| nrp1a | vegfc | ENSDARP00000140900 | ENSDARP00000092263 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.885 |