Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
taf1bTATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity). (576 aa)    
Predicted Functional Partners:
taf1a
TATA box-binding protein (TBP)-associated factor, RNA polymerase I, A.
   
 0.999
tbp
TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...]
    
 0.985
rrn3
RRN3 homolog, RNA polymerase I transcription factor.
    
 0.913
ubtf
Upstream-binding transcription factor.
   
 0.889
eaf1
ELL-associated factor 1.
    
   0.884
tbpl2
TATA box-binding protein-like protein 2; TATA box-binding transcription factor (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Commits mesoderm to the hematopoietic lineage during hemopoiesis, acting via mespa. Binds to the mespa promoter.
    
 
 0.828
wu:fj64h06
Wu:fj64h06.
    
 
 0.824
hint1
Histidine triad nucleotide-binding protein 1.
    
 
 0.824
hint2
Histidine triad nucleotide-binding protein 2.
    
 
 0.824
thap7
THAP domain-containing 7.
    
 
 0.772
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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