Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pqbp1Polyglutamine binding protein 1-like. (261 aa)    
Predicted Functional Partners:
wbp11
WW domain-binding protein 11; Activates pre-mRNA splicing.
    
 0.991
txnl4a
Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family.
   
 
 0.966
wbp11-2
WW domain-binding protein 11.
    
 
 0.956
ctnnbl1
Catenin, beta-like 1.
   
 
 0.827
cwc15
Protein CWC15 homolog; Involved in pre-mRNA splicing as component of the spliceosome.
   
 
  0.811
prpf19
PRP19/PSO4 homolog (S. cerevisiae).
   
 
  0.808
plrg1
Pleiotropic regulator 1.
   
 
  0.804
bcas2
Pre-mRNA-splicing factor SPF27; Required for pre-mRNA splicing as component of the activated spliceosome. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.
   
 
  0.802
hspa8
Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]
    
  0.802
cdc5l
CDC5 cell division cycle 5-like (S. pombe).
   
 
  0.800
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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