Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sox21aTranscription factor Sox-21-A; May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo. (239 aa)    
Predicted Functional Partners:
pou5f3
POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...]
   
 
 0.682
naif1
Nuclear apoptosis-inducing factor 1.
    
   0.551
sox4a-2
SRY-box transcription factor 4a.
      
 0.501
pax6a
Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family.
   
 
 0.496
dmrt1
Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in sex determination and differentiation by controlling gonad development and germ cell proliferation. Acts both as a transcription repressor and activator (By similarity); Belongs to the DMRT family.
    
 
 0.491
rab27b
RAB27B, member RAS oncogene family.
   
 
 0.483
rab9a
RAB9A, member RAS oncogene family.
      
 0.479
sox3
Transcription factor Sox-3; Transcriptional activator.
   
 
0.475
rab8a
RAB8A, member RAS oncogene family.
    
 
 0.471
irx3a
Iroquois 3 homeobox protein.
   
 
 0.467
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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