Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
C10H21orf91Protein EURL homolog; Plays a role in cortical progenitor cell proliferation and differentiation. May promote dendritic spine development of post- migratory cortical projection neurons by modulating the beta-catenin signaling pathway. (277 aa)    
Predicted Functional Partners:
defbl3
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.595
rflna
Family with sequence similarity 101, member A.
      
 0.594
nup54
Nucleoporin 54.
    
   0.557
ENSDARP00000151732
Nup54 domain-containing protein.
    
   0.557
traf3ip1
TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity).
   
  
 0.490
rps10
Ribosomal protein S10.
      
 0.450
neurl1ab
Neuralized E3 ubiquitin protein ligase 1Ab.
      
 0.450
neurl1aa
Neuralized E3 ubiquitin protein ligase 1Aa.
      
 0.450
neurl1b
Neuralized E3 ubiquitin protein ligase 1B.
      
 0.450
scocb
Short coiled-coil protein B; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family.
    
   0.433
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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