STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ildr2Immunoglobulin-like domain-containing receptor 2. (590 aa)    
Predicted Functional Partners:
cx28.8
Similar to gap junction membrane channel protein beta 4.
      
 0.742
LOC793236
Flavin-containing monooxygenase.
   
  
 0.720
zgc:77439
Flavin-containing monooxygenase.
   
  
 0.718
cx34.5
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.713
pctp
Phosphatidylcholine transfer protein.
      
 0.646
tbc1d1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1.
      
 0.644
phactr4a
Phosphatase and actin regulator 4A.
   
  
 0.632
tmem160
Transmembrane protein 160.
      
 0.625
phactr4a-2
Phosphatase and actin regulator 4A; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
      
 0.625
cldng
Claudin-like protein ZF-A9; Component of tight junction (TJ) strands; Belongs to the claudin family.
      
 0.580
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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