STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cnksr1Connector enhancer of kinase suppressor of Ras 1. (780 aa)    
Predicted Functional Partners:
trip10a
Cdc42-interacting protein 4 homolog; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Belongs to the FNBP1 family.
      
 0.837
rasl11b
Ras-like protein family member 11B; Belongs to the small GTPase superfamily. Ras family.
    
 
 0.692
crkl
V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.
      
 0.647
rassf1
Ras association domain family member 1.
    
 
 0.586
gtpbp4
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
   
  
 0.469
rhof
Ras homolog gene family, member F.
    
 
 0.460
stat5b
Signal transducer and activator of transcription.
      
 0.453
wdr83
WD repeat domain-containing protein 83; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha (By similarity); Belongs to the WD repeat MORG1 family.
      
 0.445
stat5a
Signal transducer and activator of transcription.
      
 0.440
arrdc2
Arrestin domain-containing 2.
   
  
 0.434
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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