STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kdm7abLysine-specific demethylase 7B; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity). (919 aa)    
Predicted Functional Partners:
kdm6bb
Lysine (K)-specific demethylase 6B, b.
   
 0.871
kdm6a
Lysine (K)-specific demethylase 6A.
   
 0.803
kdm6al
Ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1.
   
 0.780
kdm5c
Lysine (K)-specific demethylase 5C.
   
 
 0.722
kdm4c
Lysine (K)-specific demethylase 4C.
    
 
 0.721
kdm3b
Lysine (K)-specific demethylase 3B.
   
 
 0.687
kdm5a
Lysine (K)-specific demethylase 5A.
   
 
 0.687
zgc:173552
Histone H3; Belongs to the histone H3 family.
    
 0.664
zgc:113983
Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.664
kdm4b
Lysine (K)-specific demethylase 4B.
    
 
 0.663
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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