Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
kdm7abLysine-specific demethylase 7B; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity). (919 aa)    
Predicted Functional Partners:
kdm6bb
Lysine (K)-specific demethylase 6B, b.
   
 
 0.813
kdm6a
Lysine (K)-specific demethylase 6A.
   
 
 0.749
kdm5c
Lysine (K)-specific demethylase 5C.
   
 
 0.684
kdm5a
Lysine (K)-specific demethylase 5A.
   
 
 0.673
kdm6ba
Lysine (K)-specific demethylase 6B, a.
   
 
 0.667
kdm6al
Ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1.
   
 
 0.665
kdm4c
Lysine (K)-specific demethylase 4C.
   
 
 0.662
znf711
Zinc finger protein 711; Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes, leading to activate their expression (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family.
   
 
 0.641
hist2h3ca1
Histone H3; Belongs to the histone H3 family.
    
 0.641
kdm4b
Lysine (K)-specific demethylase 4B.
   
 
 0.637
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (32%) [HD]