Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
sh3rf1E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway; Belongs to the SH3RF family. (880 aa)    
Predicted Functional Partners:
tmem268
Uncharacterized protein.
      
 0.735
tmem266
Transmembrane protein 266.
      
 0.720
wdr36
WD repeat domain 36.
      
 0.714
fbxl16
F-box and leucine-rich repeat protein 16.
    
 
 0.704
synrg
Synergin, gamma.
    
 
 0.691
rhov
Novel protein similar to vertebrate ras homolog gene family, member V (RHOV).
    
  0.642
smpdl3b
Sphingomyelin phosphodiesterase acid-like 3B.
      
 0.638
dhrs7ca
Dehydrogenase/reductase SDR family member 7C-B; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.633
osbpl9
Oxysterol-binding protein; Belongs to the OSBP family.
   
  
 0.633
dhrs7cb
Dehydrogenase/reductase SDR family member 7C-A; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.633
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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