Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pkdccaProtein kinase domain-containing, cytoplasmic a. (516 aa)    
Predicted Functional Partners:
fam20cb
FAM20C golgi-associated secretory pathway kinase b.
    
 0.843
lrrk1
Leucine-rich repeat kinase 1.
    
 0.715
arl4ab
ADP-ribosylation factor-like 4, like.
    
 0.695
nrarpa
Notch-regulated ankyrin repeat-containing protein A; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family.
    
 0.614
ift140
Intraflagellar transport 140 homolog (Chlamydomonas).
      
 0.611
tm9sf1
Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
    
 0.606
slc25a33
Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria which participates in dendritic cell endocytosis; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.596
cpn1
Carboxypeptidase N, polypeptide 1.
      
 0.594
cpn1-2
Carboxypeptidase N, polypeptide 1.
      
 0.594
traf7
TNF receptor-associated factor 7.
   
  0.584
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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