STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)    
Predicted Functional Partners:
gcgb
Glucagon b.
   
 
 0.997
insra
Tyrosine-protein kinase receptor.
    
 0.990
irs1
Insulin receptor substrate 1.
     
 0.990
insrb
Tyrosine-protein kinase receptor.
    
 0.990
ghrl
Ghrelin/obestatin prepropeptide.
   
 
 0.986
igf1ra
Tyrosine-protein kinase receptor.
    
 0.985
igf1rb
Tyrosine-protein kinase receptor.
    
 0.985
irs2b
Insulin receptor substrate 2b.
     
 0.983
ide
Novel protein similar to H.sapiens IDE, insulin-degrading enzyme (IDE, zgc:162603); Belongs to the peptidase M16 family.
    
 0.982
igf1
Insulin-like growth factor 1b.
   
 
 0.979
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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