Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gnb2Guanine nucleotide-binding protein (G protein), beta polypeptide 2. (340 aa)    
Predicted Functional Partners:
gper1
G-protein coupled estrogen receptor 1; Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes.
    
 0.973
crhr1
Corticotropin-releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family.
    
 0.972
drd3
Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.
    
  0.971
calcr
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
    
  0.971
mc4r
Melanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
    
 0.970
ghsra
Growth hormone secretagogue receptor a; Belongs to the G-protein coupled receptor 1 family.
    
 0.970
oprk1
Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family.
    
  0.968
gng3
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
   
 0.965
oprm1
Opioid receptor, mu 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.964
CCKAR
Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.
    
  0.964
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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