Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
tm2d2TM2 domain-containing protein 2. (229 aa)    
Predicted Functional Partners:
tm2d1
TM2 domain-containing protein 1.
   
  
 0.977
nhlrc2
NHL repeat-containing 2.
      
 0.915
uqcc2
Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). May play a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production. May be involved in cytochrome b translation and/or stability.
    
   0.888
fam110a
Family with sequence similarity 110 member A.
      
 0.888
piga
Phosphatidylinositol glycan anchor biosynthesis, class A.
     
 0.885
pigc
Phosphatidylinositol glycan anchor biosynthesis, class C.
     
 0.882
pigh
Phosphatidylinositol glycan anchor biosynthesis, class H.
     
 0.882
pigp
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
   
 
 0.880
pigl
Phosphatidylinositol glycan anchor biosynthesis, class L.
     
 0.878
cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
     
  0.865
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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