Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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tbpl2TATA box-binding protein-like protein 2; TATA box-binding transcription factor (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Commits mesoderm to the hematopoietic lineage during hemopoiesis, acting via mespa. Binds to the mespa promoter. (312 aa)    
Predicted Functional Partners:
gtf2b
General transcription factor IIB.
   
 0.985
taf3
TAF3 RNA polymerase II, TATA box-binding protein (TBP)-associated facto.
    
 
 0.983
tbpl1
TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.
  
0.957
btaf1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated.
    
 
 0.951
taf1
Transcription initiation factor TFIID subunit.
    
 
 0.948
tbp
TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...]
     
  0.944
taf6
TAF6 RNA polymerase II, TATA box-binding protein (TBP)-associated factor.
   
 
 0.943
taf9
TAF9 RNA polymerase II, TATA box-binding protein (TBP)-associated factor.
   
 
 0.941
taf7
TAF7 RNA polymerase II, TATA box-binding protein (TBP)-associated factor.
    
 
 0.935
taf10
Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.
    
 
 0.931
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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