Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cx27.5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (254 aa)    
Predicted Functional Partners:
tgfb3
Transforming growth factor beta; Belongs to the TGF-beta family.
     
  0.819
tgfb1a
Transforming growth factor beta; Belongs to the TGF-beta family.
     
  0.652
tgfb5
Transforming growth factor beta; Belongs to the TGF-beta family.
     
  0.652
tgfb1b
Transforming growth factor beta; Belongs to the TGF-beta family.
     
  0.652
tgfb2
Transforming growth factor, beta 2.
     
  0.652
lrrc32
Leucine-rich repeat-containing 32.
     
  0.638
nrros
Transforming growth factor beta activator LRRC33; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF- beta-1 activation mediated by lrrc33/nrros is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighbo [...]
     
  0.638
rnmt
mRNA cap guanine-N7 methyltransferase; Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'- terminal GpppC; Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
      
 0.631
rhbg
Ammonium transporter Rh type B; Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity); Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
   
  
 0.595
mpzl1l
Myelin protein zero-like 1 like.
      
 0.545
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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