node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ccdc47 | ncln | ENSDARP00000051541 | ENSDARP00000076240 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.940 |
ccdc47 | sec61b | ENSDARP00000051541 | ENSDARP00000059012 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.805 |
ccdc47 | sec61g | ENSDARP00000051541 | ENSDARP00000122360 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | SEC61 translocon gamma subunit. | 0.793 |
ccdc47 | tmco1 | ENSDARP00000051541 | ENSDARP00000091049 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.984 |
ccdc47 | tmem147 | ENSDARP00000051541 | ENSDARP00000058382 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Transmembrane protein 147. | 0.929 |
ccdc47 | tmem208 | ENSDARP00000051541 | ENSDARP00000089483 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy; Belongs to the TMEM208 family. | 0.843 |
ccdc47 | tram1 | ENSDARP00000051541 | ENSDARP00000022511 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Translocating chain-associated membrane protein; Belongs to the TRAM family. | 0.819 |
ccdc47 | wdr83os | ENSDARP00000051541 | ENSDARP00000119631 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | WD repeat domain 83 opposite strand. | 0.815 |
ccdc47 | zgc:109965 | ENSDARP00000051541 | ENSDARP00000044503 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Zgc:109965. | 0.849 |
ccdc47 | zgc:113278 | ENSDARP00000051541 | ENSDARP00000026457 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Translocating chain-associated membrane protein; Belongs to the TRAM family. | 0.952 |
ncln | ccdc47 | ENSDARP00000076240 | ENSDARP00000051541 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | 0.940 |
ncln | sec61b | ENSDARP00000076240 | ENSDARP00000059012 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.764 |
ncln | sec61g | ENSDARP00000076240 | ENSDARP00000122360 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | SEC61 translocon gamma subunit. | 0.757 |
ncln | tmco1 | ENSDARP00000076240 | ENSDARP00000091049 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.909 |
ncln | tmem147 | ENSDARP00000076240 | ENSDARP00000058382 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Transmembrane protein 147. | 0.985 |
ncln | wdr83os | ENSDARP00000076240 | ENSDARP00000119631 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | WD repeat domain 83 opposite strand. | 0.571 |
sec61b | ccdc47 | ENSDARP00000059012 | ENSDARP00000051541 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | 0.805 |
sec61b | ncln | ENSDARP00000059012 | ENSDARP00000076240 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.764 |
sec61b | sec61g | ENSDARP00000059012 | ENSDARP00000122360 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | SEC61 translocon gamma subunit. | 0.999 |
sec61b | tmco1 | ENSDARP00000059012 | ENSDARP00000091049 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.805 |