Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rps6ka3aRibosomal protein S6 kinase. (732 aa)    
Predicted Functional Partners:
mapk1
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.917
mapk3
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.917
atf4a
Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity).
    
 0.901
tbc1d7
TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity).
     
 0.875
pkmyt1
Protein kinase, membrane-associated tyrosine/threonine 1.
     
  0.862
atf4b
Activating transcription factor 4b.
    
 0.849
tsc2
TSC complex subunit 2.
    
 0.837
bub1
BUB1 mitotic checkpoint serine/threonine kinase.
     
  0.808
ENSDARP00000153406
DUF3384 domain-containing protein.
    
 0.805
tsc1a
TSC complex subunit 1a.
    
 0.760
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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