| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| F6P2T1_DANRE | bcl2l1 | ENSDARP00000117759 | ENSDARP00000027919 | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Bcl-XL-like protein 1. | 0.732 |
| F6P2T1_DANRE | dnm1l | ENSDARP00000117759 | ENSDARP00000142560 | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | 0.950 |
| F6P2T1_DANRE | parl | ENSDARP00000117759 | ENSDARP00000055977 | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Presenilins-associated rhomboid-like protein, mitochondrial. | 0.526 |
| F6P2T1_DANRE | parla | ENSDARP00000117759 | ENSDARP00000057438 | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of opa1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity); Belongs to the peptidase S54 family. | 0.415 |
| F6P2T1_DANRE | pgam5 | ENSDARP00000117759 | ENSDARP00000051620 | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity); Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.974 |
| F6P2T1_DANRE | pink1 | ENSDARP00000117759 | ENSDARP00000014981 | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | PTEN-induced kinase 1. | 0.771 |
| bcl2l1 | F6P2T1_DANRE | ENSDARP00000027919 | ENSDARP00000117759 | Bcl-XL-like protein 1. | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.732 |
| bcl2l1 | dnm1l | ENSDARP00000027919 | ENSDARP00000142560 | Bcl-XL-like protein 1. | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | 0.732 |
| bcl2l1 | pgam5 | ENSDARP00000027919 | ENSDARP00000051620 | Bcl-XL-like protein 1. | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity); Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.976 |
| bcl2l1 | pink1 | ENSDARP00000027919 | ENSDARP00000014981 | Bcl-XL-like protein 1. | PTEN-induced kinase 1. | 0.989 |
| dnm1l | F6P2T1_DANRE | ENSDARP00000142560 | ENSDARP00000117759 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.950 |
| dnm1l | bcl2l1 | ENSDARP00000142560 | ENSDARP00000027919 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | Bcl-XL-like protein 1. | 0.732 |
| dnm1l | fundc1 | ENSDARP00000142560 | ENSDARP00000059836 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | 0.480 |
| dnm1l | parl | ENSDARP00000142560 | ENSDARP00000055977 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | Presenilins-associated rhomboid-like protein, mitochondrial. | 0.469 |
| dnm1l | pgam5 | ENSDARP00000142560 | ENSDARP00000051620 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity); Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.975 |
| dnm1l | pink1 | ENSDARP00000142560 | ENSDARP00000014981 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | PTEN-induced kinase 1. | 0.817 |
| fundc1 | dnm1l | ENSDARP00000059836 | ENSDARP00000142560 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] | 0.480 |
| fundc1 | parl | ENSDARP00000059836 | ENSDARP00000055977 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | Presenilins-associated rhomboid-like protein, mitochondrial. | 0.645 |
| fundc1 | parla | ENSDARP00000059836 | ENSDARP00000057438 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of opa1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity); Belongs to the peptidase S54 family. | 0.514 |
| fundc1 | pgam5 | ENSDARP00000059836 | ENSDARP00000051620 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity); Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.998 |
