node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
atg10 | atg3 | ENSDARP00000140378 | ENSDARP00000041303 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | 0.985 |
atg10 | atg4c | ENSDARP00000140378 | ENSDARP00000051778 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. | 0.845 |
atg10 | atg5 | ENSDARP00000140378 | ENSDARP00000124077 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.985 |
atg10 | atg7 | ENSDARP00000140378 | ENSDARP00000134373 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | 0.994 |
atg10 | gabarapa | ENSDARP00000140378 | ENSDARP00000051546 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | GABA(A) receptor-associated protein a. | 0.875 |
atg10 | gabarapb | ENSDARP00000140378 | ENSDARP00000068351 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | GABA(A) receptor-associated protein b. | 0.496 |
atg10 | gabarapl2 | ENSDARP00000140378 | ENSDARP00000039056 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | GABA(A) receptor-associated protein-like 2. | 0.725 |
atg10 | map1lc3a | ENSDARP00000140378 | ENSDARP00000042321 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Microtubule-associated protein 1 light chain 3 alpha. | 0.699 |
atg10 | map1lc3b | ENSDARP00000140378 | ENSDARP00000130443 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Microtubule-associated protein 1 light chain 3 beta. | 0.700 |
atg3 | atg10 | ENSDARP00000041303 | ENSDARP00000140378 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | ATG10 autophagy-related 10 homolog (S. cerevisiae). | 0.985 |
atg3 | atg4c | ENSDARP00000041303 | ENSDARP00000051778 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. | 0.889 |
atg3 | atg5 | ENSDARP00000041303 | ENSDARP00000124077 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.999 |
atg3 | atg7 | ENSDARP00000041303 | ENSDARP00000134373 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | 0.999 |
atg3 | gabarapa | ENSDARP00000041303 | ENSDARP00000051546 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | GABA(A) receptor-associated protein a. | 0.998 |
atg3 | gabarapb | ENSDARP00000041303 | ENSDARP00000068351 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | GABA(A) receptor-associated protein b. | 0.993 |
atg3 | gabarapl2 | ENSDARP00000041303 | ENSDARP00000039056 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | GABA(A) receptor-associated protein-like 2. | 0.995 |
atg3 | map1lc3a | ENSDARP00000041303 | ENSDARP00000042321 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | Microtubule-associated protein 1 light chain 3 alpha. | 0.918 |
atg3 | map1lc3b | ENSDARP00000041303 | ENSDARP00000130443 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | Microtubule-associated protein 1 light chain 3 beta. | 0.941 |
atg3 | zgc:92606 | ENSDARP00000041303 | ENSDARP00000060036 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | Zgc:92606. | 0.977 |
atg4c | atg10 | ENSDARP00000051778 | ENSDARP00000140378 | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. | ATG10 autophagy-related 10 homolog (S. cerevisiae). | 0.845 |