node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bcl9 | ctnnb1 | ENSDARP00000152762 | ENSDARP00000139205 | BCL9 transcription coactivator. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.982 |
bcl9 | ctnnb2 | ENSDARP00000152762 | ENSDARP00000076115 | BCL9 transcription coactivator. | Catenin, beta 2. | 0.924 |
bcl9 | lef1 | ENSDARP00000152762 | ENSDARP00000114249 | BCL9 transcription coactivator. | Lymphocyte enhancer binding factor 1 Lef1. | 0.883 |
bcl9 | tcf7 | ENSDARP00000152762 | ENSDARP00000128252 | BCL9 transcription coactivator. | Transcription factor 7. | 0.714 |
bcl9 | tcf7l1b | ENSDARP00000152762 | ENSDARP00000148053 | BCL9 transcription coactivator. | Transcription factor 7-like 1-B; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis. Belongs to the TCF/LEF family. | 0.784 |
bcl9 | tle2b | ENSDARP00000152762 | ENSDARP00000124214 | BCL9 transcription coactivator. | TLE family member 2, transcriptional corepressor b. | 0.499 |
bcl9 | tle3b | ENSDARP00000152762 | ENSDARP00000143498 | BCL9 transcription coactivator. | Transducin-like enhancer protein 3-B; Transcriptional corepressor that binds to a number of transcription factors; Belongs to the WD repeat Groucho/TLE family. | 0.514 |
ctnnb1 | bcl9 | ENSDARP00000139205 | ENSDARP00000152762 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | BCL9 transcription coactivator. | 0.982 |
ctnnb1 | ctnnb2 | ENSDARP00000139205 | ENSDARP00000076115 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Catenin, beta 2. | 0.924 |
ctnnb1 | lef1 | ENSDARP00000139205 | ENSDARP00000114249 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Lymphocyte enhancer binding factor 1 Lef1. | 0.999 |
ctnnb1 | nlk1 | ENSDARP00000139205 | ENSDARP00000100637 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.727 |
ctnnb1 | nlk2 | ENSDARP00000139205 | ENSDARP00000107617 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.839 |
ctnnb1 | tcf7 | ENSDARP00000139205 | ENSDARP00000128252 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Transcription factor 7. | 0.992 |
ctnnb1 | tcf7l1b | ENSDARP00000139205 | ENSDARP00000148053 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Transcription factor 7-like 1-B; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis. Belongs to the TCF/LEF family. | 0.790 |
ctnnb1 | tle2b | ENSDARP00000139205 | ENSDARP00000124214 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | TLE family member 2, transcriptional corepressor b. | 0.592 |
ctnnb1 | tle3b | ENSDARP00000139205 | ENSDARP00000143498 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Transducin-like enhancer protein 3-B; Transcriptional corepressor that binds to a number of transcription factors; Belongs to the WD repeat Groucho/TLE family. | 0.622 |
ctnnb2 | bcl9 | ENSDARP00000076115 | ENSDARP00000152762 | Catenin, beta 2. | BCL9 transcription coactivator. | 0.924 |
ctnnb2 | ctnnb1 | ENSDARP00000076115 | ENSDARP00000139205 | Catenin, beta 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.924 |
ctnnb2 | lef1 | ENSDARP00000076115 | ENSDARP00000114249 | Catenin, beta 2. | Lymphocyte enhancer binding factor 1 Lef1. | 0.993 |
ctnnb2 | nlk1 | ENSDARP00000076115 | ENSDARP00000100637 | Catenin, beta 2. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.431 |