Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
grn1Zgc:136318 protein. (147 aa)    
Predicted Functional Partners:
grn2
Granulin 2.
  
 
0.831
LOC110437757
Si:ch211-255f4.7.
   
  
 0.723
lgals3bpb
Galectin-3-binding protein B; Promotes integrin-mediated cell adhesion.
   
 
 0.603
gnl3l
Guanine nucleotide-binding protein-like 3 (nucleolar)-like.
      
 0.599
dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10.
    
 
 0.578
ctsc
Cathepsin C; Belongs to the peptidase C1 family.
   
 0.534
ccl34b.1
Chemokine (C-C motif) ligand 34b, duplicate 1.
   
  
 0.512
mki67
Marker of proliferation Ki-67.
      
 0.505
prr15la
Proline-rich protein 15-like protein A; Belongs to the PRR15 family.
      
 0.502
glrx3
Glutaredoxin 3; Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity).
    
 
 0.501
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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