STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
mosmobModulator of smoothened protein; Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation. (167 aa)    
Predicted Functional Partners:
smo
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
     
 0.881
nrsn1l
Neurensin 1-like.
      
 0.687
rhogd
Ras homolog gene family, member Ga.
      
 0.674
gpm6bb
Glycoprotein M6Bb.
      
 0.663
tspan33a
Tetraspanin-33.
     
  0.628
mgrn1b
Mahogunin, ring finger 1b.
    
 
 0.617
lingo2a
Leucine-rich repeat and Ig domain-containing 2a.
      
 0.599
tnn
Tenascin N.
      
 0.596
loxl3b
Lysyl oxidase homolog 3B; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (By similarity). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (By similarity). Can mediate oxidation of lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues (By similarity). Required for maturation of neural crest derived car [...]
    
 
 0.596
rp1l1b
Rp1-like 1b.
      
 0.594
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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