node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fgf21 | fndc5b | ENSDARP00000140850 | ENSDARP00000052107 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | 0.700 |
fgf21 | ins | ENSDARP00000140850 | ENSDARP00000051221 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.794 |
fgf21 | insb | ENSDARP00000140850 | ENSDARP00000115146 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.793 |
fgf21 | ucp1 | ENSDARP00000140850 | ENSDARP00000037614 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.691 |
fndc5b | fgf21 | ENSDARP00000052107 | ENSDARP00000140850 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | 0.700 |
fndc5b | ins | ENSDARP00000052107 | ENSDARP00000051221 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.485 |
fndc5b | insb | ENSDARP00000052107 | ENSDARP00000115146 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.486 |
fndc5b | marc1 | ENSDARP00000052107 | ENSDARP00000094269 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Mitochondrial amidoxime-reducing component 1; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] | 0.453 |
fndc5b | metrnlb | ENSDARP00000052107 | ENSDARP00000153242 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Meteorin-like, glial cell differentiation regulator b. | 0.579 |
fndc5b | mgat4a | ENSDARP00000052107 | ENSDARP00000123093 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A. | 0.543 |
fndc5b | mstnb | ENSDARP00000052107 | ENSDARP00000091159 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. | 0.688 |
fndc5b | nucb1 | ENSDARP00000052107 | ENSDARP00000071557 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Nucleobindin 1. | 0.553 |
fndc5b | ppp4r4 | ENSDARP00000052107 | ENSDARP00000120194 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Protein phosphatase 4, regulatory subunit 4. | 0.479 |
fndc5b | ucp1 | ENSDARP00000052107 | ENSDARP00000037614 | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.590 |
ins | fgf21 | ENSDARP00000051221 | ENSDARP00000140850 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | 0.794 |
ins | fndc5b | ENSDARP00000051221 | ENSDARP00000052107 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Fibronectin type III domain-containing protein 5; [Irisin]: may mediate beneficial effects of muscular exercise. | 0.485 |
ins | insb | ENSDARP00000051221 | ENSDARP00000115146 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.905 |
ins | mstnb | ENSDARP00000051221 | ENSDARP00000091159 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. | 0.542 |
ins | ucp1 | ENSDARP00000051221 | ENSDARP00000037614 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.774 |
insb | fgf21 | ENSDARP00000115146 | ENSDARP00000140850 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | 0.793 |