STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
mnx1Motor neuron and pancreas homeobox 1. (311 aa)    
Predicted Functional Partners:
isl1
Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity).
   
 
 0.848
ptf1a
Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
    
 
 0.796
olig2
Oligodendrocyte lineage transcription factor 2.
   
 
 0.786
isl2a
Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons.
   
 
 0.774
tbx20
T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.
    
 
 0.766
pax4
Paired box 4.
    
 
 0.753
LHX3
LIM/homeobox protein Lhx3.
   
 
 0.735
neurod1
Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.
    
 
 0.726
neurog3
Neurog3 protein.
    
 
 0.720
rfx6
DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Belongs to the RFX family.
      
 0.688
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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