Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ptpn2bTyrosine-protein phosphatase non-receptor type. (393 aa)    
Predicted Functional Partners:
met
MET proto-oncogene, receptor tyrosine kinase.
    
 0.929
stat1a
Signal transducer and activator of transcription.
   
 0.922
eif2ak3
Eukaryotic translation initiation factor 2-alpha kinase 3.
    
 0.777
ptpn13
Protein tyrosine phosphatase non-receptor type 13.
 
  
 
 0.760
igf1ra
Tyrosine-protein kinase receptor.
    
 0.759
insra
Tyrosine-protein kinase receptor.
    
 0.759
igf1rb
Tyrosine-protein kinase receptor.
    
 0.759
insrb
Tyrosine-protein kinase receptor.
    
 0.759
jak1
Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.
   
 0.756
hgfa
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
   
  0.755
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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