node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RANBP2 | pias4a | ENSDARP00000153036 | ENSDARP00000096293 | Si:ch1073-55a19.2. | E3 SUMO-protein ligase PIAS4-A; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity). May play a role as a transcriptional coregulator in various cellular pathways (By similarity). Negatively regulates induction of interferon phi 1 (ifnphi1) mediated by mavs and ticam1/trif. Also inhibits ifnphi1-mediated activation of the interferon-stimulated genes (ISGs) pkz and cd40, and to a lesser extent rsad2 and isg15. May inhibit ticam1/trif-mediated activation of NF-kappa-B. | 0.583 |
RANBP2 | rangap1b | ENSDARP00000153036 | ENSDARP00000072946 | Si:ch1073-55a19.2. | Ran GTPase-activating protein 1b. | 0.999 |
RANBP2 | rnf4 | ENSDARP00000153036 | ENSDARP00000138497 | Si:ch1073-55a19.2. | Ring finger protein 4. | 0.445 |
RANBP2 | sae1 | ENSDARP00000153036 | ENSDARP00000016138 | Si:ch1073-55a19.2. | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.740 |
RANBP2 | sumo3b | ENSDARP00000153036 | ENSDARP00000052255 | Si:ch1073-55a19.2. | Small ubiquitin-related modifier. | 0.997 |
RANBP2 | uba2 | ENSDARP00000153036 | ENSDARP00000139796 | Si:ch1073-55a19.2. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.791 |
RANBP2 | ube2ia | ENSDARP00000153036 | ENSDARP00000052745 | Si:ch1073-55a19.2. | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.997 |
RANBP2 | ube2ib | ENSDARP00000153036 | ENSDARP00000011487 | Si:ch1073-55a19.2. | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.996 |
nedd8 | rnf4 | ENSDARP00000021095 | ENSDARP00000138497 | NEDD8 ubiquitin-like modifier. | Ring finger protein 4. | 0.437 |
nedd8 | sae1 | ENSDARP00000021095 | ENSDARP00000016138 | NEDD8 ubiquitin-like modifier. | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.612 |
nedd8 | sumo3b | ENSDARP00000021095 | ENSDARP00000052255 | NEDD8 ubiquitin-like modifier. | Small ubiquitin-related modifier. | 0.944 |
nedd8 | uba2 | ENSDARP00000021095 | ENSDARP00000139796 | NEDD8 ubiquitin-like modifier. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.749 |
nedd8 | ube2ia | ENSDARP00000021095 | ENSDARP00000052745 | NEDD8 ubiquitin-like modifier. | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.517 |
nedd8 | ube2ib | ENSDARP00000021095 | ENSDARP00000011487 | NEDD8 ubiquitin-like modifier. | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.568 |
nedd8l | rnf4 | ENSDARP00000138920 | ENSDARP00000138497 | NEDD8 ubiquitin-like modifier, like. | Ring finger protein 4. | 0.435 |
nedd8l | sae1 | ENSDARP00000138920 | ENSDARP00000016138 | NEDD8 ubiquitin-like modifier, like. | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.608 |
nedd8l | sumo3b | ENSDARP00000138920 | ENSDARP00000052255 | NEDD8 ubiquitin-like modifier, like. | Small ubiquitin-related modifier. | 0.943 |
nedd8l | uba2 | ENSDARP00000138920 | ENSDARP00000139796 | NEDD8 ubiquitin-like modifier, like. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.749 |
nedd8l | ube2ia | ENSDARP00000138920 | ENSDARP00000052745 | NEDD8 ubiquitin-like modifier, like. | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.516 |
nedd8l | ube2ib | ENSDARP00000138920 | ENSDARP00000011487 | NEDD8 ubiquitin-like modifier, like. | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.568 |