sumo3b protein (Danio rerio) - STRING interaction network

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sumo3b

Small ubiquitin-related modifier. (94 aa)

Predicted Functional Partners:

ube2ib

0.988

pias4a

0.987

sae1

0.978

uba2

0.974

nedd8

0.949

nedd8l

0.948

rnf4

0.941

RANBP2

0.931

tp53

0.902

pcna

0.893

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RANBP2	pcna	ENSDARP00000153036	ENSDARP00000070780	Si:ch1073-55a19.2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.456
RANBP2	pias4a	ENSDARP00000153036	ENSDARP00000096293	Si:ch1073-55a19.2.	E3 SUMO-protein ligase PIAS4-A; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity). May play a role as a transcriptional coregulator in various cellular pathways (By similarity). Negatively regulates induction of interferon phi 1 (ifnphi1) mediated by mavs and ticam1/trif. Also inhibits ifnphi1-mediated activation of the interferon-stimulated genes (ISGs) pkz and cd40, and to a lesser extent rsad2 and isg15. May inhibit ticam1/trif-mediated activation of NF-kappa-B.	0.568
RANBP2	rnf4	ENSDARP00000153036	ENSDARP00000138497	Si:ch1073-55a19.2.	Ring finger protein 4.	0.520
RANBP2	sae1	ENSDARP00000153036	ENSDARP00000016138	Si:ch1073-55a19.2.	SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family.	0.715
RANBP2	sumo3b	ENSDARP00000153036	ENSDARP00000052255	Si:ch1073-55a19.2.	Small ubiquitin-related modifier.	0.931
RANBP2	tp53	ENSDARP00000153036	ENSDARP00000116736	Si:ch1073-55a19.2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.920
RANBP2	uba2	ENSDARP00000153036	ENSDARP00000139796	Si:ch1073-55a19.2.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family.	0.721
RANBP2	ube2ib	ENSDARP00000153036	ENSDARP00000011487	Si:ch1073-55a19.2.	SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family.	0.920
nedd8	nedd8l	ENSDARP00000021095	ENSDARP00000138920	NEDD8 ubiquitin-like modifier.	NEDD8 ubiquitin-like modifier, like.	0.643
nedd8	pcna	ENSDARP00000021095	ENSDARP00000070780	NEDD8 ubiquitin-like modifier.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.492
nedd8	rnf4	ENSDARP00000021095	ENSDARP00000138497	NEDD8 ubiquitin-like modifier.	Ring finger protein 4.	0.416
nedd8	sae1	ENSDARP00000021095	ENSDARP00000016138	NEDD8 ubiquitin-like modifier.	SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family.	0.642
nedd8	sumo3b	ENSDARP00000021095	ENSDARP00000052255	NEDD8 ubiquitin-like modifier.	Small ubiquitin-related modifier.	0.949
nedd8	tp53	ENSDARP00000021095	ENSDARP00000116736	NEDD8 ubiquitin-like modifier.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.585
nedd8	uba2	ENSDARP00000021095	ENSDARP00000139796	NEDD8 ubiquitin-like modifier.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family.	0.740
nedd8	ube2ib	ENSDARP00000021095	ENSDARP00000011487	NEDD8 ubiquitin-like modifier.	SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family.	0.583
nedd8l	nedd8	ENSDARP00000138920	ENSDARP00000021095	NEDD8 ubiquitin-like modifier, like.	NEDD8 ubiquitin-like modifier.	0.643
nedd8l	pcna	ENSDARP00000138920	ENSDARP00000070780	NEDD8 ubiquitin-like modifier, like.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.478
nedd8l	rnf4	ENSDARP00000138920	ENSDARP00000138497	NEDD8 ubiquitin-like modifier, like.	Ring finger protein 4.	0.416
nedd8l	sae1	ENSDARP00000138920	ENSDARP00000016138	NEDD8 ubiquitin-like modifier, like.	SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family.	0.640

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