Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thap11THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). (257 aa)    
Predicted Functional Partners:
znf143b
Zinc finger protein 143; Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the activator element (AE) motif of the selenocysteine tRNA gene promoter (By similarity). Belongs to the GLI C2H2-type zinc-finger protein family.
     
 0.991
hcfc1a
Host cell factor C1a.
   
  
 0.956
znf76
Zinc finger protein 76.
     
  0.915
gins1
GINS complex subunit 1 (Psf1 homolog).
    
 
 0.880
mcm9
DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart (By similarity).
   
 
 0.877
mcm2
DNA helicase; Belongs to the MCM family.
   
 
 0.877
gins4
DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.
   
 
 0.865
gins2
DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.
   
 
 0.861
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 
 0.860
mcm4
DNA helicase; Belongs to the MCM family.
   
 
 0.844
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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