STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
traddTumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd. (293 aa)    
Predicted Functional Partners:
tnfrsf1a
Tumor necrosis factor receptor superfamily, member 1a.
   
 0.999
ripk1l
Receptor (TNFRSF)-interacting serine-threonine kinase 1,-like.
   
 0.999
traf5
Tnf receptor-associated factor 5.
    
 0.999
fadd
Fas (tnfrsf6)-associated via death domain.
   
 0.999
traf2a
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.998
ripk3
Receptor-interacting serine-threonine kinase 3.
   
 0.998
traf2b
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.998
casp8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 0.995
casp22
Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.992
birc2
Baculoviral IAP repeat-containing 2.
   
 0.991
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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