STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cd81aTetraspanin. (236 aa)    
Predicted Functional Partners:
tsg101a
Tumor susceptibility 101a.
      
 0.964
cd63
Tetraspanin.
  
 
0.812
cd9a
Tetraspanin.
  
 
 
0.807
cldn1
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
      
 0.759
hsp70.1
Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family.
   
  
 0.750
hsp70.3
Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family.
   
  
 0.749
sdcbp2
Syndecan-binding protein (syntenin) 2.
   
 
 0.706
hsp90aa1.1
Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...]
   
  
 0.685
sdcbp
Syndecan-binding protein (syntenin).
    
 
 0.684
ptgfrn
Uncharacterized protein.
    
 
 0.684
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.