Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lctlaLactase-like a; Belongs to the glycosyl hydrolase 1 family. (552 aa)    
Predicted Functional Partners:
galm
Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.
  
 
 0.702
gusb
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.
    
 0.687
ugdh
UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
    
 0.666
rgn
Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
  
 
  0.640
gkup
Glucuronokinase with putative uridyl pyrophosphorylase.
    
 0.636
miox
Inositol oxygenase; Belongs to the myo-inositol oxygenase family.
   
 
  0.626
ganc
Glucosidase, alpha; neutral C; Belongs to the glycosyl hydrolase 31 family.
  
 0.560
ydjc
Carbohydrate deacetylase; Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. Belongs to the YdjC deacetylase family.
  
 
 0.554
bfsp2
Beaded filament structural protein 2, phakinin; Belongs to the intermediate filament family.
   
 
  0.551
glb1l
Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.
  
 
 0.548
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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