node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acvr1l | rargb | ENSDARP00000003221 | ENSDARP00000142165 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.564 |
crabp2b | rargb | ENSDARP00000039596 | ENSDARP00000142165 | Duplicated cellular retinoic acid-binding protein 2b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.576 |
crx | rargb | ENSDARP00000030526 | ENSDARP00000142165 | Cone-rod homeobox. | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.524 |
cyp26a1 | rargb | ENSDARP00000041727 | ENSDARP00000142165 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.602 |
cyp26a1 | rars1 | ENSDARP00000041727 | ENSDARP00000107383 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.959 |
ncor2 | rargb | ENSDARP00000051138 | ENSDARP00000142165 | Nuclear receptor corepressor 2. | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.508 |
ncor2 | rars1 | ENSDARP00000051138 | ENSDARP00000107383 | Nuclear receptor corepressor 2. | Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.667 |
rargb | acvr1l | ENSDARP00000142165 | ENSDARP00000003221 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.564 |
rargb | crabp2b | ENSDARP00000142165 | ENSDARP00000039596 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Duplicated cellular retinoic acid-binding protein 2b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.576 |
rargb | crx | ENSDARP00000142165 | ENSDARP00000030526 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Cone-rod homeobox. | 0.524 |
rargb | cyp26a1 | ENSDARP00000142165 | ENSDARP00000041727 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.602 |
rargb | ncor2 | ENSDARP00000142165 | ENSDARP00000051138 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Nuclear receptor corepressor 2. | 0.508 |
rargb | rars1 | ENSDARP00000142165 | ENSDARP00000107383 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.712 |
rargb | tnni1d | ENSDARP00000142165 | ENSDARP00000151197 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Troponin I, skeletal, slow d. | 0.486 |
rargb | tnni4a | ENSDARP00000142165 | ENSDARP00000145428 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Troponin I4a. | 0.486 |
rargb | tnni4b.1 | ENSDARP00000142165 | ENSDARP00000143338 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Troponin I4b, tandem duplicate 1. | 0.486 |
rargb | wnt9b | ENSDARP00000142165 | ENSDARP00000055224 | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.485 |
rars1 | cyp26a1 | ENSDARP00000107383 | ENSDARP00000041727 | Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.959 |
rars1 | ncor2 | ENSDARP00000107383 | ENSDARP00000051138 | Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Nuclear receptor corepressor 2. | 0.667 |
rars1 | rargb | ENSDARP00000107383 | ENSDARP00000142165 | Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.712 |