| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| agmat | agxt2 | ENSDARP00000135941 | ENSDARP00000136125 | Agmatine ureohydrolase (agmatinase); Belongs to the arginase family. | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.803 |
| agmat | aldh4a1 | ENSDARP00000135941 | ENSDARP00000142254 | Agmatine ureohydrolase (agmatinase); Belongs to the arginase family. | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.955 |
| agmat | arg2 | ENSDARP00000135941 | ENSDARP00000057376 | Agmatine ureohydrolase (agmatinase); Belongs to the arginase family. | Arginase. | 0.652 |
| agmat | gamt | ENSDARP00000135941 | ENSDARP00000095135 | Agmatine ureohydrolase (agmatinase); Belongs to the arginase family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | 0.465 |
| agmat | gatm | ENSDARP00000135941 | ENSDARP00000052640 | Agmatine ureohydrolase (agmatinase); Belongs to the arginase family. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). | 0.969 |
| agmat | gldc | ENSDARP00000135941 | ENSDARP00000135421 | Agmatine ureohydrolase (agmatinase); Belongs to the arginase family. | Glycine dehydrogenase (decarboxylating). | 0.471 |
| agxt2 | agmat | ENSDARP00000136125 | ENSDARP00000135941 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Agmatine ureohydrolase (agmatinase); Belongs to the arginase family. | 0.803 |
| agxt2 | alas1 | ENSDARP00000136125 | ENSDARP00000005771 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 5-aminolevulinate synthase. | 0.965 |
| agxt2 | alas2 | ENSDARP00000136125 | ENSDARP00000056419 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.961 |
| agxt2 | aldh4a1 | ENSDARP00000136125 | ENSDARP00000142254 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.594 |
| agxt2 | arg2 | ENSDARP00000136125 | ENSDARP00000057376 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Arginase. | 0.610 |
| agxt2 | gatm | ENSDARP00000136125 | ENSDARP00000052640 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). | 0.971 |
| agxt2 | gldc | ENSDARP00000136125 | ENSDARP00000135421 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glycine dehydrogenase (decarboxylating). | 0.983 |
| agxt2 | gnmt | ENSDARP00000136125 | ENSDARP00000007584 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glycine N-methyltransferase. | 0.968 |
| agxt2 | sardh | ENSDARP00000136125 | ENSDARP00000154120 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Sarcosine dehydrogenase. | 0.969 |
| alas1 | agxt2 | ENSDARP00000005771 | ENSDARP00000136125 | 5-aminolevulinate synthase. | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.965 |
| alas1 | alas2 | ENSDARP00000005771 | ENSDARP00000056419 | 5-aminolevulinate synthase. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.984 |
| alas1 | arg2 | ENSDARP00000005771 | ENSDARP00000057376 | 5-aminolevulinate synthase. | Arginase. | 0.453 |
| alas1 | gatm | ENSDARP00000005771 | ENSDARP00000052640 | 5-aminolevulinate synthase. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). | 0.960 |
| alas1 | gldc | ENSDARP00000005771 | ENSDARP00000135421 | 5-aminolevulinate synthase. | Glycine dehydrogenase (decarboxylating). | 0.966 |