Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rras2Related RAS viral (R-ras) oncogene homolog 2. (202 aa)    
Predicted Functional Partners:
map3k1
Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
    
 0.978
sos2
Son of sevenless homolog 2 (Drosophila).
    
 0.977
braf
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.974
pik3cd
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.972
pik3cb
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
    
 0.972
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.
    
 0.971
araf
A-Raf proto-oncogene, serine/threonine kinase.
    
 0.967
nf1a
Neurofibromin 1a.
    
 0.966
sos1
Son of sevenless homolog 1 (Drosophila).
   
 0.963
shoc2
Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and stimulate raf1 activity at specialized signaling complexes (By similarity).
   
 0.960
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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